Histoid leprosy is a skin condition, a rare form of multibacillary leprosy See also. Leprosy · Skin lesion. References. ^ James, William D.; Berger. Histoid leprosy, an uncommon variant of lepromatous leprosy, develops usually as relapse in lepromatous patients who are on dapsone. Summary Histoid leprosy is a rare multibacillary form that presents with disseminated papule-nodular cutaneous lesions. To study the inflammatory infiltrate.
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The lesions are usually located on the posterior and lateral aspects of the arms, buttocks, thighs, dorsum of the hands, lower part of the back, and over the bony prominences, especially over elbows and knees. Histoid leprosy might represent an enhanced response of the multibacillary disease in localizing the disease process.
How to cite this article: Lepromatous leprosy of histoid type: Sengal VN, Srivastava G. Histoid lesions have also been found along the course of the peripheral nerve trunks and cutaneous nerves.
There is male preponderance, and the average age affected is between 21 and 40 years [ 2 ]. Author information Article notes Copyright and License information Disclaimer.
A year-old young male, an agricultural laborer, complained of multiple asymptomatic shiny nodules all over the body. Please review our hitsoid policy. Family history was non-contributory.
It is so-called because the microscopic appearance of the nodule shows spindle-shaped cells resembling those in a dermatofibroma. Histoid leprosy is a distinct and rare variant of lepromatous leprosy, and it was described by Wade 1 in Histoid leprosy is not uncommon in South India.
Histoid lesions have also been reported to present along the course of the peripheral nerve trunks and cutaneous nerves.
Click on image for details. Actinobacteria primarily A00—A79—, — The impact of the entity on the postglobal leprosy elimination era. Histoid leprosy in North India. The palms and soles are usually not affected in histoid leprosy [ 1 ]. Lepromatous leprosy of histoid type.
Received Oct 20; Accepted Dec However, whether histoid should be treated as other multibacillary forms or other immunotherapies should be added to the treatment regimen deserves consideration. Histoid Hansens clinically simulates dermatofibromas, xanthomas, neurofibromas, reticulohistiocytosis, and cutaneous metastasis.
Each of them can be differentiated from the histoid leprosy on the basis of its characteristic histopathology, the absence of lepra bacilli on slit skin smear and nerve thickening.
De-novo Histoid Leprosy
The peripheral nerves may be thickened [ 2 ] or normal [ 5 ]. There are three histological variants of histoid Hansens, namely, pure fusocellular, fusocellular with epitheloid component, and fusocellular with vacuolated cells.
Table of Contents Alerts. Responsible factors may include: The most prominent feature is the presence of numerous spindle-shaped histiocytes arranged in interlacing bands, whorls, and tight curlicues. Report from so-called nonendemic areas. However, specific histopathology of histoid leprosy differentiates it from LL type which shows macrophage granuloma with variable amount of foamy changes with innumerable bacilli and globi and ENL reaction which shows features of acute inflammation predominantly having neutrophils accompanied by edema along with granular AFB.
This lepprosy has been cited by 1 Curcumin could prevent methemoglobinemia induced by dapsone in rats Mateus M.
Histoid leprosy – Wikipedia
Journal of Clinical and Diagnostic Research. Clinical examination revealed multiple discrete, skin-colored, shiny cutaneous and subcutaneous nodules keprosy the trunk and limbs. Histoid leprosy A Review. Histoid leprosy is a variant of Lepromatous leprosy believed to occur due to a mutant strain of leprosy bacillus called as Histoid Bacillus.